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Bimuno is the result of intensive research development dating back to 2000 and conducted in collaboration with the University of Reading's Food Microbial Sciences Unit and other globally recognized research institutes.

The research was supported by funding provided by the Biotechnology, Biological Sciences, Research Council (BBSRC).

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The research showed for the first time that the modulation of gut microbiota by prebiotics can lead to changes in brain biochemistry. The study is published in the journal Neurochemistry International, entitled 'Prebiotic feeding elevates central brain derived neurotrophic factor, N methyl D aspartate receptor subunits and D serine'.

Reading and Oxford, UK, January 23, 2014 Clasado, the manufacturers and suppliers of the second generation prebiotic Bimuno, and The Department of Psychiatry, University of Oxford, today announce the results of pre clinical research demonstrating prebiotics affect the relationship between the gut and the brain. This collaborative research will complement and serve as a precursor to current human trials.

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Second generation GOS intake, which induced the greatest elevation of bifidobacteria compared to FOS and controls led to an increase of NR1 and NR2A subunits in the hypocampus and NR1 subunits and D serine in the frontal cortex. The administration of FOS, which caused a relatively minor proliferation of bifidobacteria, increased the levels of NR1 in the hypocampus only. However, FOS administration also raised the concentration of hippocampal BDNF, an effect previously observed with probiotics.

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disturbances in neuropsychiatric illness and age related decline.

The researchers hope that the findings could offer insight into the potential treatment of cognitive dysfunction, emotional Omega Seamaster 300 Master

Clasado And University of Oxford Demonstrate Effect Of Prebiotics On Brain And Gut In Pre Clinical

Prebiotic technology could prove to be a useful contribution to the management and treatment of depressive disorders, particularly as unlike some existing drug therapies it is Omega Seamaster Rose Gold free from unwanted side effects. Clasado hopes to demonstrate that the addition of specific prebiotics to the diet of an ageing population could hold real benefits in ensuring an improved quality of life. Clasado is committed to discovering, developing and harnessing the latest ground breaking prebiotic technology, providing clinically proven solutions which improve and enrich the quality of people's lives.

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"There is a growing body of evidence linking the gut to various aspects of brain health," said Geoff Collins, Head of Consumer Marketing, Clasado. "We are hopeful that this new research, the first of its kind using a prebiotic, will pave the way for further discoveries and potential brain associated health applications for this technology."

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the complex interactions between the gut and brain," said Dr Phil Burnet, head researcher, University Department of Psychiatry, University of Oxford. "Our results have also provided the basis for further research in humans."

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Further studies will determine whether the increase in NMDA and BDNF were as a result of factors other than only microbiota. This is because there is some evidence suggesting that 2nd generation prebiotics such as Bimuno may also interact directly with the gut. Further research is also needed to test whether the changes seen in the rat brain translate to improved neural function and behaviour, and whether prebiotics can benefit human brain health.

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"The study has provided valuable insights into Omega Seamaster 300 Ceramic

In the trial, rats were fed either FOS (fructo oligosaccahride) or second generation GOS (galacto oligosaccharide) prebiotics (Bimuno). In both cases significant effects on the neuronal biochemistry of the rats were demonstrated. These effects are believed to have resulted from changes in the gut microbiota including an increase in bifidobacteria facilitated via the feeding of prebiotics. Brain Derived Neurotrophic Factor (BDNF), an important molecule involved in the development and maintenance of neural cells, increased in the brain after repeated ingestion of prebiotics, compared with rats that did not receive the prebiotics. Additionally, components of the N methyl D aspartate (NMDA) receptor, which have a critical role in brain development, learning and memory, also increased in the rat brain after just two weeks of daily prebiotic feedings.

Human clinical trials have recently been conducted by Clasado and The Department of Psychiatry, University of Oxford. Enrolment for this study was completed in Q4, 2012 with the study itself having been completed at the end of 2013. The results of the study are due to be published in the coming months.

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